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Phospho-IkappaB beta (Ser19) Polyclonal Antibody, Invitrogen™

Catalog No. PIPA599388
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PIPA599388 100 μL
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Catalog No. PIPA599388 Supplier Thermo Scientific Supplier No. PA599388

Item Discontinued This item has been discontinued by the supplier. Please to view product availability in your area.

Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of IKB beta only when phosphorylated at Ser19.

The NF-kB/Rel transcription factors are present in the cytosol in an inactive state, complexed with the inhibitory IkB proteins. Most agents that activate NF-kB do so through a common pathway based on phosphorylation-induced, proteasome-mediated degradation of IkB. The key regulatory step in this pathway involves activation of a high molecular weight IkB kinase (IKK) complex whose catalysis is generally carried out by three tightly associated IKK subunits. IKK alpha and IKK beta serve as the catalytic subunits of the kinase and IKK gamma serves as the regulatory subunit. Activation of IKK depends upon phosphorylation at Ser177 and Ser181 in the activation loop of IKK beta (Ser176 and Ser180 in IKK alpha), which causes conformational changes, resulting in kinase activation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-IkappaB beta (Ser19)
Applications Immunocytochemistry, Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene NFKBIB
Gene Accession No. Q15653
Gene Alias I kappa B beta; I(Kappa)B(beta); ikappaBbeta; I-kappa-B-beta; IkB; IKB B; IKB beta; Ikbb; ikB-B; IkBbeta; ikB-beta; NF kappa BIB; NF-kappa-B inhibitor beta; NF-kappa-BIB; NFKB inhibitor beta; NFKBIB; nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, beta; nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta; Thyroid receptor; thyroid receptor-interacting protein 9; TR-interacting protein 9; TRIP 9; TRIP9; TRIP-9
Gene Symbols NFKBIB
Host Species Rabbit
Immunogen A synthesized peptide derived from human NFKBIB(Accession Q15653), corresponding to amino acid residues around phosphorylated Ser19.
Purification Method sequential chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 4793
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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