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Phospho-IKB beta (Ser23) Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501985209
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50-198-5209 100 μL
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Catalog No. 50-198-5209 Supplier Bioss Supplier No. BS3191R
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Description

Rabbit Polyclonal Antibody

The NF-kB/Rel transcription factors are present in the cytosol in an inactive state, complexed with the inhibitory IkB proteins. Most agents that activate NF-kB do so through a common pathway based on phosphorylation-induced, proteasome-mediated degradation of IkB. The key regulatory step in this pathway involves activation of a high molecular weight IkB kinase (IKK) complex whose catalysis is generally carried out by three tightly associated IKK subunits. IKK alpha and IKK beta serve as the catalytic subunits of the kinase and IKK gamma serves as the regulatory subunit. Activation of IKK depends upon phosphorylation at Ser177 and Ser181 in the activation loop of IKK beta (Ser176 and Ser180 in IKK alpha), which causes conformational changes, resulting in kinase activation.

Specifications

Antigen Phospho-IKB beta (Ser23)
Applications Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene NFKBIB
Gene Accession No. Q15653
Gene Alias BOS_17535; I kappa B beta; I(Kappa)B(beta); IKappaBbeta; I-kappa-B-beta; IkB; IKB B; IKB beta; IKBB; IkB-B; IkBbeta; IKB-beta; LOC100359283; NF kappa BIB; NF-kappa-B inhibitor beta; NF-kappa-BIB; NFKB inhibitor beta; NFKBIB; nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, beta; nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta; Thyroid receptor; Thyroid receptor-interacting protein 9; TR-interacting protein 9; TRIP 9; TRIP9; TRIP-9
Gene Symbols NFKBIB
Host Species Rabbit
Immunogen KLH conjugated synthetic phosphopeptide derived from human NFKBIB around the phosphorylation site of Ser23.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 4793
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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