Phospho-IKB epsilon (Ser157) Rabbit anti-Human, Polyclonal, Bioss

Rabbit Polyclonal Antibody

Supplier:  Bioss BS5517R

Catalog No. 50-198-6619

Description

NFKB1 or NFKB2 is bound to REL, RELA, or RELB to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008 or NFKBIB, MIM 604495), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine). For some genes, activation requires NFKB interaction with other transcription factors, such as STAT (see STAT6, MIM 601512), AP1 (JUN, MIM 165160), and NFAT (see NFATC1, MIM 600489).

Specifications

• Antigen: Phospho-IKB epsilon (Ser157)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Nfkbie
• Gene Alias: ikappaBepsilon; I-kappa-B-epsilon; IkB epsilon; IKBE; IkB-E; IkBepsilon; ikB-epsilon; NF-kappa-B inhibitor epsilon; NF-kappa-BIE; NFKB inhibitor epsilon; NFKBIE; nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, epsilon; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon; Slc35b2; solute carrier family 35, member B2
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 4794
• Content And Storage: -20°C
• Form: Liquid

• Applications: ELISA, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 μg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
• Gene Accession No.: O00221
• Gene Symbols: Nfkbie
• Immunogen: KLH conjugated synthetic phosphopeptide derived from human NFKBIE around the phosphorylation site of Ser157.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG