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Phospho-IKK alpha (Tyr463) Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501985239
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50-198-5239 100 μL
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Catalog No. 50-198-5239 Supplier Bioss Supplier No. BS3234R
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Description

Rabbit Polyclonal Antibody

Inhibitor of Nuclear factor Kappa-B kinase subunit alpha (IKK alpha) is encoded by the CHUK gene and located on chromosome 10 in humans. It is also known as IKK1 or CHUK (Conserved helix-loop-helix ubiquitous kinase). IKK alpha belongs to the family of serine threonine protein kinase and forms a part of IKK complex. The IKK complex is required for the activation of NF-kB with IKK alpha specifically known to be involved in the non-canocial pathway for NF-kB activation. IKK alpha along with IKK beta and a regulatory protein NEMO (IKK gamma) phosphorylates IkB proteins which targets the later for ubiquitin mediated degradation. It is involved with several cellular processes with extensive studies on its role in inflammation and cell survival.

Specifications

Antigen Phospho-IKK alpha (Tyr463)
Applications Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene CHUK
Gene Accession No. O15111
Gene Alias AI256658; BOS_23346; CHUK; Chuk1; Conserved helix-loop-helix ubiquitous kinase; EC 2.7.11.10; Fbx24; Fbxo24; FLJ40509; I kappa B kinase 1; i kappa-B kinase alpha; ikappaB kinase; I-kappa-B kinase 1; I-kappa-B kinase 2; IkappaB kinase alpha; I-kappa-B kinase alpha; I-kappa-B kinase-alpha; IkB kinase alpha subunit; Ikbka; IKBKB; IKK alpha; IKK1; IKK2; IKKA; IKK-A; IKK-a kinase; IKK-alpha; IKKB; IKK-B; IKK-beta; Inhibitor of nuclear factor kappa-B kinase subunit alpha; kinase beta; MGC131801; NFKBIKA; NFKBIKB; Nuclear factor NFkappaB inhibitor kinase alpha; Nuclear factor NF-kappa-B inhibitor kinase alpha; TCF16; TCF-16; Transcription factor 16
Gene Symbols CHUK
Host Species Rabbit
Immunogen KLH conjugated synthetic phosphopeptide derived from human IKK alpha around the phosphorylation site of Tyr463.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1147
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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