Invitrogen™ Phospho-IL4R (Tyr497) Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA538614

Catalog No. PIPA538614

Description

Phospho-IL4R (Tyr497) Polyclonal Antibody for Western Blot, ICC/IF

IL4 Receptor alpha (IL4RA) is the alpha chain of the interleukin 4 receptor which binds to both interleukin 4 and interleukin 13 to regulate IgE production, chemokine and mucus production at sites of allergic inflammmation. The IL4 response is involved in promoting Th2 differentiation. The secreted extracellular domain of IL4R alpha, called sIL4R alpha, can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. It has no signaling abilities. Allelic variations in the IL4RA gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema.

Specifications

• Antigen: Phospho-IL4R (Tyr497)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: IL4R
• Gene Alias: 582J2.1; CD124; il-4 receptor; IL-4 receptor alpha chain; IL-4 receptor subunit alpha; IL-4-binding protein; IL4-BP; Il4r; IL4R nirs variant 1; IL-4R subunit alpha; IL4RA; IL-4RA; IL-4R-alpha; interleukin 4 receptor; interleukin 4 receptor, alpha; interleukin-4 receptor alpha chain; interleukin-4 receptor subunit alpha; Soluble IL-4 receptor subunit alpha; Soluble interleukin-4 receptor subunit alpha
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 16190, 3566
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: P16382, P24394
• Gene Symbols: IL4R, Il4ra
• Immunogen: A synthetic phosphopeptide derived from human IL-4R/CD124 around the phosphorylation site of Tyr497 (P-A-YP-R-S).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov