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Invitrogen™ Phospho-IR/IGF1R beta (Tyr1135, Tyr1136, Tyr1150, Tyr1151) Recombinant Rabbit Monoclonal Antibody (S.326.5)
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Catalog No. PIMA515148
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PIMA515148 100 μL
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Catalog No. PIMA515148 Supplier Invitrogen™ Supplier No. MA515148
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Description

Rabbit Recombinant Monoclonal Antibody

It is not recommended to aliquot this antibody. This antibody is not cross-reactive with other related tyrosine-phosphorylated tyrosine kinases.

Type I insulin-like growth factor receptor (IGF-IR) is a transmembrane receptor tyrosine kinase that is widely expressed in many cell lines and cell types within fetal and postnatal tissues. Receptor autophosphorylation follows binding of the IGF-I and IGF-II ligands. Three tyrosine residues within the kinase domain (Tyr1131, Tyr1135, and Tyr1136) are the earliest major autophosphorylation sites. Phosphorylation of these three tyrosine residues is necessary for kinase activation. Insulin receptors (IRs) share significant structural and functional similarity with IGF-I receptors, including the presence of an equivalent tyrosine cluster (Tyr1146/1150/1151) within the kinase domain activation loop. Tyrosine autophosphorylation of IRs is one of the earliest cellular responses to insulin stimulation. Autophosphorylation begins with phosphorylation at Tyr1146 and either Tyr1150 or Tyr1151, while full kinase activation requires triple tyrosine phosphorylation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-IR/IGF1R beta (Tyr1135, Tyr1136, Tyr1150, Tyr1151)
Applications Western Blot
Classification Recombinant Monoclonal
Clone S.326.5
Concentration 243 μg/mL
Conjugate Unconjugated
Formulation 0.01M HEPES with 100 μg/mL BSA, 50% glycerol, 0.15M NaCl and <0.02% sodium azide; pH 7.5
Gene INSR
Gene Accession No. P06213, P08069, P15127, P15208, P24062, Q60751
Gene Alias IGF1 Receptor beta, IGF-I Receptor beta, IGF1R beta, CD221, IGFIR, IGFR, JTK13, IGF-I receptor, insulin-like growth factor I receptor, soluble IGF1R variant 1, soluble IGF1R variant 2, CD220, HHF5, INSR, Insulin receptor beta
Gene Symbols IGF1R, INSR
Host Species Rabbit
Immunogen Synthetic phosphopeptide corresponding to residues surrounding pTyr1135/1136 of human IGF-I receptor β.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 16001, 16337, 24954, 25718, 3480, 3643
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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