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Invitrogen™ Phospho-IRAK4 (Thr345, Ser346) Polyclonal Antibody
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Catalog No. PIPA5102849
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PIPA5102849 100 μL
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Catalog No. PIPA5102849 Supplier Invitrogen™ Supplier No. PA5102849
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of IRAK4 only when phosphorylated at Thr345/Ser346.

IL-1 receptor associated kinases (IRAKs) are serine/threonine kinases involved in signaling via Toll/IL-1 pathways. Overexpression of IRAK-4 activates NF-kappa-B and MAPK pathways. IRAK-4 interacts with and phosphorylates IRAK-1. IRAK-4-deficient animals are completely resistant to the challenge with LPS. Animals and humans lacking IRAK-4 are impaired in their responses to viral and bacterial challenges. Members in IRAK/Pelle family play a central role in IL-1R/TLR mediated inflammatory responses and in innate immunity.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-IRAK4 (Thr345, Ser346)
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene IRAK4
Gene Accession No. Q8R4K2, Q9NWZ3
Gene Alias 8430405M07Rik; 9330209D03Rik; interleukin 1 receptor associated kinase 4; interleukin-1; interleukin-1 receptor-associated kinase 4; IPD1; Irak4; IRAK-4; NY-REN-64; REN64; renal carcinoma antigen NY-REN-64
Gene Symbols IRAK4
Host Species Rabbit
Immunogen A synthesized peptide derived from human IRAK4(Accession Q9NWZ3), corresponding to amino acid residues around phosphorylated Ser346.
Purification Method Sequential chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 266632, 300177, 51135
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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