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Invitrogen™ Phospho-IRS1 (Ser307) Polyclonal Antibody
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Catalog No. PIPA5143361
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100 μL
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Catalog No. Quantity
PIPA5143361 100 μL
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Catalog No. PIPA5143361 Supplier Invitrogen™ Supplier No. PA5143361
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Description

Rabbit Polyclonal Antibody

Store as concentrated solution. Centrifuge briefly prior to opening vial. Positive control: C2C12 (100 nM Insulin treatment for 30 min).

IRS-1, a major substrate of the insulin receptor, is phosphorylated in response to stimulation of cells by insulin, insulin-like growth factor 1 (IGF-1) and interleukin 4 (IL-4). IRS-1 is phosphorylated on serine, threonine and tyrosine residues in a variety of tissues. An insulin-sensitive serine/threonine kinase casein kinase II mediates a portion of the insulin-stimulated serine/threonine phosphorylation of overexpressed IRS-1 in vivo. Thr 502 is identified as the major casein kinase II-catalyzed phosphorylation site in rat IRS-1, and Ser 99 is an additional phosphorylation site catalyzed by casein kinase II. Thus, casein kinase II-catalyzed phosphorylation of IRS-1 may be a component of the intracellular insulin signaling cascade. IRS-1 contains three putative binding sites for 14-3-3 (Ser 270, Ser 374 and Ser 641) and the motif around Ser 270 is located in the phosphortyrosine binding domain of IRS-1, which is responsible for the interaction with the insulin receptor.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-IRS1 (Ser307)
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1.51 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 20% glycerol and 0.025% Proclin 300; pH 7
Gene IRS1
Gene Accession No. P35568, P35569, P35570
Gene Alias G972R; HIRS-1; Insulin receptor substrate 1; IRS1; IRS-1; IRS1IRM; pp185
Gene Symbols IRS1
Host Species Rabbit
Immunogen Carrier-protein conjugated synthetic peptide surrounding phospho Ser307 of human IRS1. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 16367, 25467, 3667
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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