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Phospho-IRS1 (Tyr896) Rabbit anti-Human, Polyclonal, Bioss

Rabbit Polyclonal Antibody
Supplier: Bioss BS3204R

Description
IRS-1, a major substrate of the insulin receptor, is phosphorylated in response to stimulation of cells by insulin, insulin-like growth factor 1 (IGF-1) and interleukin 4 (IL-4). IRS-1 is phosphorylated on serine, threonine and tyrosine residues in a variety of tissues. An insulin-sensitive serine/threonine kinase casein kinase II mediates a portion of the insulin-stimulated serine/threonine phosphorylation of overexpressed IRS-1 in vivo. Thr 502 is identified as the major casein kinase II-catalyzed phosphorylation site in rat IRS-1, and Ser 99 is an additional phosphorylation site catalyzed by casein kinase II. Thus, casein kinase II-catalyzed phosphorylation of IRS-1 may be a component of the intracellular insulin signaling cascade. IRS-1 contains three putative binding sites for 14-3-3 (Ser 270, Ser 374 and Ser 641) and the motif around Ser 270 is located in the phosphortyrosine binding domain of IRS-1, which is responsible for the interaction with the insulin receptor.Specifications
Phospho-IRS1 (Tyr896) | |
Polyclonal | |
Unconjugated | |
IRS1 | |
G972R; HIRS-1; Insulin receptor substrate 1; IRS1; Irs-1; IRS1IRM; pp185 | |
Rabbit | |
Protein A | |
RUO | |
3667 | |
-20°C | |
Liquid |
ELISA, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot | |
1 μg/mL | |
PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH | |
P35568 | |
IRS1 | |
KLH conjugated synthetic phosphopeptide derived from human IRS1 around the phosphorylation site of Tyr896 [GE (p-Y)VN]. | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG |
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