Invitrogen™ Phospho-JAK1 (Tyr1034) Polyclonal Antibody

Phospho-JAK1 (Tyr1022) Polyclonal Antibody

Supplier:  Invitrogen™ PA537617

Catalog No. PIPA537617

Description

Phospho-JAK1 (Tyr1022) Polyclonal Antibody for Western Blot, IHC (P)

Janus kinase 1 (JAK1), is a protein tyrosine kinase that is involved in the interferon-alpha/beta and -gamma signal transduction pathways. Immunological stimuli, such as interferons and cytokines, induce recruitment of Stat transcription factors to cytokine receptor-associated JAK1. JAK1 then phosphorylates proximal Stat factors, which subsequently dimerize, translocate to the nucleus and bind to cis elements upstream of target gene promoters to regulate transcription. Upon ligand binding, JAK1 undergoes tyrosine phosphorylation and catalytic activation in an interdependent manner. Phosphorylation of tyrosine residues at positions 1022 and 1023 is believed to function in the activation of catalytic events.

Specifications

• Antigen: Phospho-JAK1 (Tyr1034)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: JAK1
• Gene Alias: AA960307; BAP004; C130039L05Rik; EC 2.7.10.2; Jak1; JAK-1; JAK1A; JAK1B; Janus kinase 1; Janus protein tyrosine kinase 1; JTK3; kinase Jak1; Tyrosine-protein kinase JAK1
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 16451, 3716, 84598
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.5% BSA, 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: P23458, P52332
• Gene Symbols: JAK1
• Immunogen: Peptide sequence around phosphorylation site of tyrosine 1034 (K-E-Y(p)-Y-T) derived from Human JAK1.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG