Phospho-Jak3 (Tyr980, Tyr981) Recombinant Rabbit Monoclonal Antibody (JAK3Y980981-E10), FITC, Invitrogen™

Rabbit Recombinant Monoclonal Antibody

Catalog Number	Mfr. No.	Quantity
PIMA537450	Invitrogen™ MA537450	10 Tests
PIMA537202	Invitrogen™ MA537202	100 Tests

Description

Janus kinase 3 (JAK3) phosphorylates members of the STAT (signal transduction and activators of transcription) family. JAK3 is predominantly expressed in immune cells and transduces a signal in response to activation of interleukin receptors. In response to a varitety of cytokine or related factors (e.g., interferon, interleukins), JAKs are activated via phosphorylation at 2 adjacent tyrosine residues. The activation of JAKs can lead to the phosphorylation of STAT (signal transducers and activatiors of transcription) proteins, which dimerize and translocate to the nucleus. Once translocated to the nucleus, the STAT proteins can modify transcription of numerous genes, including interferon-stimulated genes. JAK2 is required for the IFN gamma-receptor complex initiation and JAK1 functions as an amplifier. However, active JAK1 may be required for complex responses. Some studies have suggested that the role of JAK2 might be performed by Tyk2 and JAK3, if they were positioned correctly within the IFN gamma-receptor complex.

Specifications

• Antigen: Phospho-Jak3 (Tyr980, Tyr981)
• Applications: Flow Cytometry
• Conjugate: FITC
• Host Species: Rabbit
• Target Species: Human
• Gene Accession No.: P52333
• Gene ID (Entrez): 3718
• Immunogen: A synthetic phospho-peptide corresponding to residues surrounding Tyr980/981 of human Jak3.
• Primary or Secondary: Primary
• Content And Storage: 4°C, store in dark
• Gene: JAK3

• Clone: JAK3Y980981-E10
• Classification: Recombinant Monoclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 0.20% BSA and 0.09% sodium azide
• Gene Alias: Breast-JAK3; fae; JAK3; JAK-3; JAK3_HUMAN; JAK3B; JAKL; Janus kinase 3; Janus kinase 3 (a protein tyrosine kinase, leukocyte); Janus kinase 3 protein-tyrosine kinase; Janus kinase 3, protein-tyrosine kinase; L JAK; Leukocyte janus kinase; LJAK; L-JAK; RATJAK3; Tyrosine-protein kinase JAK3; wil
• Gene Symbols: JAK3
• Isotype: IgG κ
• Purification Method: Protein A/G
• Product Type: Antibody