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Invitrogen™ Phospho-JIP1 (Thr103) Polyclonal Antibody
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Catalog No. PIPA5103270
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Quantity:
100 μL
Catalog No. Quantity
PIPA5103270 100 μL
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Catalog No. PIPA5103270

Supplier: Invitrogen™ PA5103270

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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of JIP1 only when phosphorylated at Thr103.

The protein encoded by this gene is a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-JIP1 (Thr103)
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene MAPK8IP1
Gene Accession No. Q9R237, Q9UQF2, Q9WVI9
Gene Alias C-Jun-amino-terminal kinase-interacting protein 1; Ib1; IB-1; Islet-brain 1; islet-brain-1; JIP1; JIP-1; JIP-1-related protein; JNK MAP kinase scaffold protein 1; JNK-interacting protein 1; JRP; Mapk8ip; Mapk8ip1; mitogen activated protein kinase 8 interacting protein; mitogen activated protein kinase 8 interacting protein 1; mitogen-activated protein kinase 8 interacting protein 1; mitogen-activated protein kinase 8-interacting protein 1; mjip-2a; PRKM8 interacting protein; PRKM8IP; protein kinase, mitogen-activated 8 interacting protein; Skip
Gene Symbols MAPK8IP1
Host Species Rabbit
Immunogen A synthesized peptide derived from human MAPK8IP1(Accession Q9UQF2), corresponding to amino acid residues around phosphorylated Thr103.
Purification Method Sequential Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 116457, 19099, 9479
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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