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Invitrogen™ Phospho-JNK1 (Thr183, Tyr185) Polyclonal Antibody
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Catalog No. PIPA5117403
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PIPA5117403 100 μL
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Catalog No. PIPA5117403 Supplier Invitrogen™ Supplier No. PA5117403
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Description

Rabbit Polyclonal Antibody

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MAPK8 (JNK1) is activated by the presence of misfolded proteins in the endoplasmic reticulum. It is also a crucial mediator of insulin resistance and obesity. It belongs to the MAPK superfamily of stress-activated protein kinases. MAPKs are Serine-threonine protein kinases that are activated in response to a variety of extracellular stimuli, and mediate signal transduction from the cell surface to the nucleus. JNK is involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. JNK pathways are activated by stress and inflammatory signals. JNK is expressed as ten different isoforms due to differential mRNA splicing. The predominant forms are JNK1 and JNK2.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-JNK1 (Thr183, Tyr185)
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1.09 mg/mL
Conjugate Unconjugated
Formulation PBS with 20% glycerol, 1% BSA and 0.025% ProClin 300; pH 7
Gene MAPK8
Gene Accession No. P45983, Q91Y86
Gene Alias AI849689; c-Jun N-terminal kinase 1; FLJ12099; FLJ33785; JNK; JNK1; JNK1 beta1 protein kinase; jnk1a-1; JNK1A2; JNK21B1/2; JNK-46; JUN N-terminal kinase; MAP kinase 8; MAPK 8; Mapk8; mapk8 protein; mapk8b; MGC50974; mitogen activated protein kinase 8; mitogen-activated protein kinase 8; mitogen-activated protein kinase 8 isoform JNK1 alpha1; mitogen-activated protein kinase 8 isoform JNK1 beta2; mitogen-activated protein kinase 8b; OTTHUMP00000019552; p493F12; p54 gamma; p54bSAPK; PRKM8; protein kinase JNK1; protein kinase mitogen-activated 8; SAPK gamma; SAPK1; SAPK1C; stress-activated protein kinase 1; stress-activated protein kinase 1c; Stress-activated protein kinase JNK1; zgc:112379
Gene Symbols MAPK8
Host Species Rabbit
Immunogen Carrier-protein conjugated synthetic peptide surrounding phospho Thr183/Tyr185 of human JNK. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 26419, 5599
Target Species Human, Mouse, Drosophila
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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