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Phospho-KAP-1 (Ser824) Recombinant Rabbit Monoclonal Antibody (BL-246-7B5), Bethyl Laboratories
Rabbit Recombit Monoclonal Antibody
$157.08 - $378.84
Specifications
Antigen | Phospho-KAP-1 (Ser824) |
---|---|
Clone | BL-246-7B5 |
Applications | Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blot |
Classification | Recombinant Monoclonal |
Conjugate | Unconjugated |
Catalog Number | Mfr. No. | Quantity | Price | Quantity & Availability | |||||
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Catalog Number | Mfr. No. | Quantity | Price | Quantity & Availability | |||||
50-157-1280
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Bethyl Laboratories, Inc
A700013T |
20 μL |
Each for $157.08
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50-157-1279
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Bethyl Laboratories, Inc
A700013 |
100 μL |
Each for $378.84
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Description
The recommended shelf life for this product is 1 year from date of receipt. Application Note: For ICC, formaldehyde fixation is recommended. Permeabilization with Triton-X 100 is recommended for formaldehyde-fixed cells. For IHC, epitope retrieval with c
The KRAB (Kruppel-associated box) domain is about 45 amino acids in length and is a transcriptional repression domain found in numerous transcription factors. There have been identified over 220 KRAB-zinc finger protein (KRAB-ZFP) genes in the human genome. These proteins functionally repress transcription via specific interactions with KAP-1 (KRAB-associated protein 1). KAP-1 is an 835 amino acid polypeptide that contains a RING finger, B boxes, and a PHD finger. KAP-1 has been shown to form complexes with KRAB-domain transcription factors and increase the efficiency with which they mediate repression. KAP-1 has also been shown to directly interact with HP1 (heterochromatin protein 1) and KRAZ1 (Kruppel-associated box-containing zinc finger protein 1). KAP-1 directly targets KRAZ1 to the foci of centromeric heterochromatin containing HP1alpha, thus helping to regulate transcriptional repression. Studies have shown that KAP-1 mutants with the ability to bind KRAB but unable to bind HP1 leads to random distribution of KRAZ1 and strong transcriptional activation.Specifications
Phospho-KAP-1 (Ser824) | |
Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blot | |
Unconjugated | |
Rabbit | |
Human | |
Q13263 | |
10155 | |
Surrounding serine 824 | |
Primary | |
4° C | |
TRIM28 |
BL-246-7B5 | |
Recombinant Monoclonal | |
Liquid | |
RUO | |
BBS with 0.1% BSA and 0.09% sodium azide; pH 8.2 | |
Transcription intermediary factor 1-beta, Tripartite motif protein 28, Nuclear corepressor KAP-1, KRAB-associated protein 1, KAP-1, KRAB-interacting p | |
TRIM28 | |
IgG | |
Purified | |
Antibody |
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