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Phospho-KAP-1 (Ser824) Recombinant Rabbit Monoclonal Antibody (BL-246-7B5), Bethyl Laboratories

Rabbit Recombit Monoclonal Antibody

$157.08 - $378.84

Specifications

Antigen Phospho-KAP-1 (Ser824)
Clone BL-246-7B5
Applications Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blot
Classification Recombinant Monoclonal
Conjugate Unconjugated
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
50-157-1280
Encompass_Preferred
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Bethyl Laboratories, Inc
A700013T
20 μL
Each for $157.08
Only null left
Add to Cart
 
50-157-1279
Encompass_Preferred
View Documents
Bethyl Laboratories, Inc
A700013
100 μL
Each for $378.84
Only null left
Add to Cart
 
Description

Description

The recommended shelf life for this product is 1 year from date of receipt. Application Note: For ICC, formaldehyde fixation is recommended. Permeabilization with Triton-X 100 is recommended for formaldehyde-fixed cells. For IHC, epitope retrieval with c

The KRAB (Kruppel-associated box) domain is about 45 amino acids in length and is a transcriptional repression domain found in numerous transcription factors. There have been identified over 220 KRAB-zinc finger protein (KRAB-ZFP) genes in the human genome. These proteins functionally repress transcription via specific interactions with KAP-1 (KRAB-associated protein 1). KAP-1 is an 835 amino acid polypeptide that contains a RING finger, B boxes, and a PHD finger. KAP-1 has been shown to form complexes with KRAB-domain transcription factors and increase the efficiency with which they mediate repression. KAP-1 has also been shown to directly interact with HP1 (heterochromatin protein 1) and KRAZ1 (Kruppel-associated box-containing zinc finger protein 1). KAP-1 directly targets KRAZ1 to the foci of centromeric heterochromatin containing HP1alpha, thus helping to regulate transcriptional repression. Studies have shown that KAP-1 mutants with the ability to bind KRAB but unable to bind HP1 leads to random distribution of KRAZ1 and strong transcriptional activation.
Specifications

Specifications

Phospho-KAP-1 (Ser824)
Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blot
Unconjugated
Rabbit
Human
Q13263
10155
Surrounding serine 824
Primary
4° C
TRIM28
BL-246-7B5
Recombinant Monoclonal
Liquid
RUO
BBS with 0.1% BSA and 0.09% sodium azide; pH 8.2
Transcription intermediary factor 1-beta, Tripartite motif protein 28, Nuclear corepressor KAP-1, KRAB-associated protein 1, KAP-1, KRAB-interacting p
TRIM28
IgG
Purified
Antibody
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