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Invitrogen™ Phospho-KCNH2 (Ser1137) Polyclonal Antibody
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Catalog No. PIPA5105315
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PIPA5105315 100 μL
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Catalog No. PIPA5105315 Supplier Invitrogen™ Supplier No. PA5105315
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of KCNH2 only when phosphorylated at Ser1137.

Human ether-a-go-go related gene (HERG) encodes the pore-forming alpha subunit of the delayed rectifier potassium channel IKr. There are two N-terminal splice variants of HERG include the full-length isoform 1 alpha and the shorter isoform 1 beta. Isoform 1 beta lacks the PAS motif and deactivates at a faster rate than isoform 1alpha. Residues within the C-terminal play a role in channel expression and channel gating, including voltage-dependent activation. HERG is expressed in the heart and is more abundantly expressed in the ventricles than in the atria. Mutations in the gene encoding HERG increase beat-to-beat variability and early after depolarization. These fluctuations facilitate the genesis and propagation of premature heartbeats associated with inheritable long QT syndrome type 2 and short QT syndrome type 1.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-KCNH2 (Ser1137)
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene KCNH2
Gene Accession No. O08962, O35219, Q12809
Gene Alias AI326795; cerg; c-ERG; cERG; ether-a-go-go related member 2; delayed rectifier potassium channel; derg; Eag homolog; eag related protein 1; eag-related gene; eag-related protein 1; ERG; ERG1; ERG-1; ether-a-go-go related gene potassium channel 1; ether-a-go-go related protein; ether-a-go-go-related gene potassium channel 1; ether-a-go-go-related potassium channel protein; ether-a-go-go-related protein 1; gp-erg; HERG; H-ERG; HERG1; HERG-1; KCNH2; Kv11.1; LQT; Lqt2; M-erg; Merg1; M-erg1; merg1a; merg1b; potassium channel; potassium channel protein ERG; potassium channel protein ERG long isoform; potassium channel protein ERG short isoform; potassium channel, voltage gated eag related subfamily H, member 2; potassium voltage-gated channel subfamily H member 2; potassium voltage-gated channel, subfamily H (eag-related), member 2; ra-erg; RERG; r-ERG; SQT1; ventricular ERG K+ channel subunit; voltage-gated potassium channel 11.1; voltage-gated potassium channel subunit Kv11.1; voltage-gated potassium channel variant 3; voltage-gated potassium channel, subfamily H, member 2
Gene Symbols KCNH2
Host Species Rabbit
Immunogen A synthesized peptide derived from human KCNH2(Accession Q12809), corresponding to amino acid residues around phosphorylated Ser1137.
Purification Method Sequential chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 117018, 16511, 3757
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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