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Invitrogen™ Phospho-KIF1B (Ser1057) Polyclonal Antibody
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Catalog No. PIPA5105403
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PIPA5105403 100 μL
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Catalog No. PIPA5105403 Supplier Invitrogen™ Supplier No. PA5105403
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of KIF1B only when phosphorylated at Ser1057.

The kinesins constitute a large family of microtubule-dependent motor proteins, which are responsible for the distribution of numerous organelles, vesicles and macromolecular complexes throughout the cell. Individual kinesin members play crucial roles in cell division, intracellular transport and membrane trafficking events including endocytosis and transcytosis. KIF1B is a member of the KIF1/Unc104 family of kinesin-like proteins that are involved in the transport of mitochondria or synaptic vesicles in axons. KIF1B is an amino-terminal-type motor protein that is ubiquitously expressed, with the most abundant levels in differentiated nerve cells. The human KIF1B gene maps to chromosome 1p36. 2. Defects in axonal transport due to mutations at the KIF1B gene can underlie the human peripheral neuropathy phenotype. The mouse KIF1B gene generates an alternatively spliced transcript, which produces two isoforms.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-KIF1B (Ser1057)
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene KIF1B
Gene Accession No. O60333, O88658, Q60575
Gene Alias A530096N05Rik; AI448212; AI506502; CMT2; CMT2A; CMT2A1; D4Mil1e; HMSNII; KIAA0591; KIAA1448; Kif1b; KIF1Bp130; KIF1Bp204; kinesin family member 1B; kinesin heavy chain member 1B; kinesin superfamily protein KIF1B; kinesin-family protein KIF1Bbeta3; kinesin-like protein KIF1B; Klp; N-3 kinesin; NBLST1
Gene Symbols KIF1B
Host Species Rabbit
Immunogen A synthesized peptide derived from human KIF1B(Accession O60333), corresponding to amino acid residues around phosphorylated Ser1057.
Purification Method sequential chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 117548, 16561, 23095
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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