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Invitrogen™ Phospho-KIF1C (Ser1092) Polyclonal Antibody
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Catalog No. PIPA5105829
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PIPA5105829 100 μL
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Catalog No. PIPA5105829 Supplier Invitrogen™ Supplier No. PA5105829
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of KIF1C only when phosphorylated at Ser1092.

The kinesins constitute a large family of microtubule-dependent motor proteins, which are responsible for the distribution of numerous organelles, vesicles and macromolecular complexes throughout the cell. Individual kinesin members play crucial roles in cell division, intracellular transport, and membrane trafficking events including endocytosis and transcytosis. KIF1C is a member of the KIF1/Unc104 family of kinesin-like proteins, which are involved in the transport of mitochondria or synaptic vesicles in axons. Human KIF1C maps to chromosome 17p13 and encodes a predicted 1,103 amino acid protein with abundant expression in heart and skeletal muscle. Tyrosine phosphorylation is a putative regulator of KIF1C mediated retrograde transport of Golgi vesicles to the endoplasmic reticulum. KIF1C is capable of forming homodimers and can noncovalently associate with 14-3-3 beta, gamma, epsilon and zeta. In mouse macrophages, KIF1C is required for anthrax lethal toxin resistance.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-KIF1C (Ser1092)
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene KIF1C
Gene Accession No. O35071, O35787, O43896
Gene Alias B430105J22Rik; D11Bwg1349e; KIAA0706; Kif1c; Kif1d; kinesin 1C; kinesin family member 1C; kinesin superfamily protein 1C; kinesin-like protein KIF1C; Kinesin-like protein KIF1D; lethal factor toxin susceptibility 1; Ltxs1; N-3 kinsin; SATX2; SAX2; spastic ataxia 2 (autosomal recessive); SPAX2; SPG58
Gene Symbols KIF1C
Host Species Rabbit
Immunogen A synthesized peptide derived from human KIF1C(Accession O43896), corresponding to amino acid residues around phosphorylated Ser1092.
Purification Method Sequential Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 10749, 113886, 16562
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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