Invitrogen™ Phospho-KIF1C (Ser1092) Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5105829

Catalog No. PIPA5105829

Description

Antibody detects endogenous levels of KIF1C only when phosphorylated at Ser1092.

The kinesins constitute a large family of microtubule-dependent motor proteins, which are responsible for the distribution of numerous organelles, vesicles and macromolecular complexes throughout the cell. Individual kinesin members play crucial roles in cell division, intracellular transport, and membrane trafficking events including endocytosis and transcytosis. KIF1C is a member of the KIF1/Unc104 family of kinesin-like proteins, which are involved in the transport of mitochondria or synaptic vesicles in axons. Human KIF1C maps to chromosome 17p13 and encodes a predicted 1,103 amino acid protein with abundant expression in heart and skeletal muscle. Tyrosine phosphorylation is a putative regulator of KIF1C mediated retrograde transport of Golgi vesicles to the endoplasmic reticulum. KIF1C is capable of forming homodimers and can noncovalently associate with 14-3-3 beta, gamma, epsilon and zeta. In mouse macrophages, KIF1C is required for anthrax lethal toxin resistance.

Specifications

• Antigen: Phospho-KIF1C (Ser1092)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: KIF1C
• Gene Alias: B430105J22Rik; D11Bwg1349e; KIAA0706; Kif1c; Kif1d; kinesin 1C; kinesin family member 1C; kinesin superfamily protein 1C; kinesin-like protein KIF1C; Kinesin-like protein KIF1D; lethal factor toxin susceptibility 1; Ltxs1; N-3 kinsin; SATX2; SAX2; spastic ataxia 2 (autosomal recessive); SPAX2; SPG58
• Host Species: Rabbit
• Purification Method: Sequential Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 10749, 113886, 16562
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: O35071, O35787, O43896
• Gene Symbols: KIF1C
• Immunogen: A synthesized peptide derived from human KIF1C(Accession O43896), corresponding to amino acid residues around phosphorylated Ser1092.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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