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Invitrogen™ Phospho-KSR2 (Thr497) Polyclonal Antibody
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Catalog No. PIPA5105093
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100 μL
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Catalog No. Quantity
PIPA5105093 100 μL
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Catalog No. PIPA5105093 Supplier Invitrogen™ Supplier No. PA5105093
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of KSR2 only when phosphorylated at Thr497.

KSR2 serine/threonine kinase or kinase suppressor of Ras 2 specifically regulates the activity of MEKK3 and COT but not other members of the MAP3K family. KSR interacts with a regulatory Raf molecule in cis to induce a conformational switch of MEK, facilitating MEK's phosphorylation by a separate catalytic Raf molecule in trans. Blocks MAP3K8 kinase activity and MAP3K8- mediated signaling. Acts as a negative regulator of MAP3K3- mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-KSR2 (Thr497)
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene KSR2
Gene Accession No. Q3UVC0, Q6VAB6
Gene Alias hKSR2; Kinase suppressor of Ras 2; ksr2; RGD1562674; testes-kinase suppressor of ras 2 isoform
Gene Symbols KSR2
Host Species Rabbit
Immunogen A synthesized peptide derived from human KSR2(Accession Q6VAB6), corresponding to amino acid residues around phosphorylated Thr497.
Purification Method Sequential Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 283455, 288691, 333050
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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