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Invitrogen™ Phospho-L-Plastin (Ser5) Polyclonal Antibody
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Catalog No. PIPA5105825
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PIPA5105825 100 μL
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Catalog No. PIPA5105825 Supplier Invitrogen™ Supplier No. PA5105825
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of Plastin L only when phosphorylated at Ser5.

L-plastin is a leukocyte specific actin bundling protein from fimbrin family of proteins. It has two actin-binding domains and two EF hand type calcium-binding domains. It gets phosphorylated on the serine residue in its headpiece region in response to a variety of inflammatory stimuli. It is hypothesized that L-plastin may play a role in regulating integrin mediated adhesion in leukocytes. L-plastin is expressed in majority of human cancer cell lines derived from solid tumors. Its expression is positively upregulated by testosterones in androgen receptor positive prostrate and breast cancer cells through three androgen receptor binding elements located in the upstream region of the gene.
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Specifications

Antigen Phospho-L-Plastin (Ser5)
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene LCP1
Gene Accession No. P13796, Q61233
Gene Alias 65 kDa macrophage protein; AW536232; bA139H14.1 (lymphocyte cytosolic protein 1 (L-plastin)); cb245; CP64; D14Ertd310e; DKFZp781A23186; epididymis secretory protein Li 37; fj24b12; FLJ25423; FLJ26114; FLJ39956; HEL-S-37; LC64P; LCP1; LCP-1; leucocyte-specific plastin 1; L-fimbrin; LPL; L-plastin; L-plastin (Lymphocyte cytosolic protein 1) (LCP-1) (65 kDa macrophage protein) (PP65); L-plastin (Lymphocyte cytosolic protein 1) (LCP-1) (LC64P); lymphocyte cytosolic plastin 1; lymphocyte cytosolic protein 1; lymphocyte cytosolic protein 1 (L-plastin); Lymphocyte cytosolic protein-1 (plasmin); plastin 2; plastin 2, L; plastin-2; Pls2; pp65; wu:fj24b12
Gene Symbols LCP1
Host Species Rabbit
Immunogen A synthesized peptide derived from human LCP1(Accession P13796), corresponding to amino acid residues around phosphorylated Ser5.
Purification Method sequential chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 18826, 306071, 3936
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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