Invitrogen™ Phospho-LAT (Tyr191) Polyclonal Antibody

Catalog No.	Quantity
PIPA5121346	100 μL

Catalog No. PIPA5121346 Supplier Invitrogen™ Supplier No. PA5121346

Description

Rabbit Polyclonal Antibody

Positive test controls include: Jurkat, NIH/3T3. The target is usually found in the following locations: Cell membrane, Single-pass type III membrane protein. Immunogen sequence: REYVN.

LAT (Linker for Activation of T cells) is a 36-38 kDa double-palmitoylated transmembrane adaptor protein expressed by T cells, pre-B cells, NK cells, mast cells and platelets. After immunoreceptor triggering, LAT becomes multiply tyrosine-phosphorylated by Syk-, Src-, or Tec-family kinases, providing docking sites for downstream signaling molecules. LAT is essential for TCR-dependent T cell- and FcepsilonRI-dependent mast cell activation, as well as for maturation of early thymocytes. It is also involved in NK cell signaling and platelet activation.

Specifications

• Antigen: Phospho-LAT (Tyr191)
• Applications: ELISA, Western Blot
• Classification: Polyclonal
• Concentration: 2.04 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene: LAT
• Gene Accession No.: O43561, O54957
• Gene Alias: 36 kDa phospho-tyrosine adapter protein; 36 kDa phospho-tyrosine adaptor protein; Lat; LAT1; linker for activation of T cells; linker for activation of T cells, transmembrane adaptor; linker for activation of T-cells; linker for activation of T-cells family member 1; linker protein; p36-38; pp36
• Gene Symbols: LAT
• Host Species: Rabbit
• Immunogen: A synthetic phosphorylated peptide around Y191 of human LAT (NP_001014987.1).
• Purification Method: Affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 16797, 27040
• Target Species: Human, Mouse
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG