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Invitrogen™ Phospho-LATS1/LATS2 (Thr1079, Thr1041) Polyclonal Antibody
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Catalog No. PIPA537834
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PIPA537834 100 μL
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Catalog No. PIPA537834 Supplier Invitrogen™ Supplier No. PA537834
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Description

Rabbit Polyclonal Antibody

A suggested positive control for IHC is human brain tissue.

The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-LATS1/LATS2 (Thr1079, Thr1041)
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Lats1
Gene Accession No. O95835, Q7TSJ6, Q8BYR2, Q9NRM7
Gene Alias 4932411G09Rik; AV277261; AW208599; AW228608; h-warts; kinase phosphorylated during mitosis protein; KPM; large tumor suppressor; large tumor suppressor 2; large tumor suppressor homolog 1; Large tumor suppressor homolog 2; large tumor suppressor kinase 1; large tumor suppressor kinase 2; large tumor suppressor, homolog 2; large tumor supressor, homolog 1; LATS (large tumor suppressor, Drosophila) homolog 1; LATS (large tumor suppressor, Drosophila) homolog 2; LATS, large tumor suppressor, homolog 1; LATS, large tumor suppressor, homolog 2; lats1; Lats2; RGD1564085; serine/threonine kinase KPM; serine/threonine-protein kinase kpm; Serine/threonine-protein kinase LATS1; serine/threonine-protein kinase LATS2; WARTS; WARTS protein kinase; warts-like kinase; wts
Gene Symbols Lats1, Lats2
Host Species Rabbit
Immunogen Peptide sequence around phosphorylation site of threonine 1079/1041 (E-F-T(p)-F-R) derived from Human LATS1/2.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 16798, 26524, 50523, 9113
Target Species Human, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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WARNING: Cancer - www.P65Warnings.ca.gov
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