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Invitrogen™ Phospho-LIMK1/LIMK2 (Thr508, Thr505) Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA538078
Description
Phospho-LIMK1/LIMK2 (Thr508, Thr505) Polyclonal Antibody for Western Blot, IHC (P)
Proteins containing LIM motifs are typically involved in cell fate determination and growth control. A family of proteins designated LIM kinases, including LIMK-1 and LIMK-2, has been identified. LIMK-1 has been shown to regulate the stabilization of F-Actin structures and cofilin activity, indicating that LIMK-1 plays a role in a signaling pathway involved in the regulation of cell motility and morphogenesis. LIMK-1 inhibits neuronal differentiation of PC12 cells, and is thought to act by interfering with events downstream of MAPK activation. Expression patterns of LIMK-1 and LIMK-2 suggest that these proteins may have different functions during development. A truncated form of LIMK-2 has been identified in adult testis that is thought to arise from an alternative initiation exon.
Specifications
Phospho-LIMK1/LIMK2 (Thr508, Thr505) | |
Polyclonal | |
Unconjugated | |
LIMK1 | |
KIZ-1; LIM domain kinase 1; LIM domain kinase 2; lim kinase 1; LIM kinase 2; LIM motif-containing protein kinase; LIM motif-containing protein kinase 1; LIM motif-containing protein kinase 2; LIM-domain containing protein kinase 1; LIM-domain containing, protein kinase; LIM-domain containing, protein kinase 1; Limk; LIMK 2; LIMK1; LIMK-1; LIMK2; LIMK-2; Limk2b; Link2 | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
16885, 16886, 29524, 3984, 3985, 65172 | |
-20°C | |
Liquid |
Immunohistochemistry (Paraffin), Western Blot | |
1 mg/mL | |
Dulbecco's PBS with 50% glycerol and 0.02% sodium azide; pH 7.4 | |
O54785, P53667, P53668, P53669, P53670, P53671 | |
LIMK1, LIMK2 | |
A synthetic phosphopeptide derived from human LIMK1/2 around the phosphorylation site of Thr508/505. | |
100 μg | |
Primary | |
Human, Mouse, Rat | |
Antibody | |
IgG |
Safety and Handling
WARNING: Cancer - www.P65Warnings.ca.gov
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