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Invitrogen™ Phospho-LIMK1/LIMK2 (Thr508, Thr505) Polyclonal Antibody
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Catalog No. PIPA5104924
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PIPA5104924 100 μL
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Catalog No. PIPA5104924 Supplier Invitrogen™ Supplier No. PA5104924
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of LIMK1/2 only when phosphorylated at Threonine 508/505.

Proteins containing LIM motifs are typically involved in cell fate determination and growth control. A family of proteins designated LIM kinases, including LIMK-1 and LIMK-2, has been identified. LIMK-1 has been shown to regulate the stabilization of F-Actin structures and cofilin activity, indicating that LIMK-1 plays a role in a signaling pathway involved in the regulation of cell motility and morphogenesis. LIMK-1 inhibits neuronal differentiation of PC12 cells, and is thought to act by interfering with events downstream of MAPK activation. Expression patterns of LIMK-1 and LIMK-2 suggest that these proteins may have different functions during development. A truncated form of LIMK-2 has been identified in adult testis that is thought to arise from an alternative initiation exon.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-LIMK1/LIMK2 (Thr508, Thr505)
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene LIMK1
Gene Accession No. O54785, P53667, P53668, P53669, P53670, P53671
Gene Alias KIZ-1; LIM domain kinase 1; LIM domain kinase 2; lim kinase 1; LIM kinase 2; LIM motif-containing protein kinase; LIM motif-containing protein kinase 1; LIM motif-containing protein kinase 2; LIM-domain containing protein kinase 1; LIM-domain containing, protein kinase; LIM-domain containing, protein kinase 1; Limk; LIMK 2; LIMK1; LIMK-1; LIMK2; LIMK-2; Limk2b; Link2
Gene Symbols LIMK1, LIMK2
Host Species Rabbit
Immunogen A synthesized peptide derived from human LIMK1(Accession P53667), corresponding to amino acid residues around phosphorylated Thr508.
Purification Method sequential chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 16885, 16886, 29524, 3984, 3985, 65172
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

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