Phospho-LIMK2 (Ser283) Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA539719

Catalog No. PIPA539719

Description

Proteins containing LIM motifs are typically involved in cell fate determination and growth control. A family of proteins designated LIM kinases, including LIMK-1 and LIMK-2, has been identified. LIMK-1 has been shown to regulate the stabilization of F-Actin structures and cofilin activity, indicating that LIMK-1 plays a role in a signaling pathway involved in the regulation of cell motility and morphogenesis. LIMK-1 inhibits neuronal differentiation of PC12 cells, and is thought to act by interfering with events downstream of MAPK activation. Expression patterns of LIMK-1 and LIMK-2 suggest that these proteins may have different functions during development. A truncated form of LIMK-2 has been identified in adult testis that is thought to arise from an alternative initiation exon.

Specifications

• Antigen: Phospho-LIMK2 (Ser283)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: LIMK2
• Gene Alias: LIM domain kinase 1, LIMK-1, LIMK1, LIMK, LIM domain kinase 2, LIMK 2, LIMK2
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 16886, 29524, 3985
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 1 mg/mL
• Formulation: Dulbecco′s PBS with 150mM NaCl, 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: P53671, O54785, P53670
• Gene Symbols: LIMK2
• Immunogen: A synthetic phosphopeptide derived from human LIMK2 around the phosphorylation site of Ser283 (R-R-SP-L-R)
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG