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Invitrogen™ Phospho-LIMK2 (Thr505) Polyclonal Antibody
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Catalog No. PIPA536664
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PIPA536664 100 μL
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Catalog No. PIPA536664 Supplier Invitrogen™ Supplier No. PA536664
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Description

Rabbit Polyclonal Antibody

This antibody detects endogenous protein at a molecular weight of 72 kDa. Purity is >95% by SDS-PAGE.

LIMK2 is a serine/threonine kinase involved in regulation of actin cytoskeletal changes via phosphorylation of cofilin. LIMK2 has also been implicated in brain development. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by LIMK2 is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for LIMK2.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-LIMK2 (Thr505)
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
Gene LIMK2
Gene Accession No. O54785, P53670, P53671
Gene Alias EC 2.7.11.1; kinase LIMK2; LIM domain kinase 2; LIM kinase 2; LIM motif-containing protein kinase 2; LIMK; LIMK 2; LIMK1; LIMK-1; Limk2; LIMK-2; Limk2b; LINhp-2; Link2; OTTHUMP00000199483
Gene Symbols LIMK2
Host Species Rabbit
Immunogen Synthetic phosphopeptide derived from human LIMK2 around the phosphorylation site of Threonine 505.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 16886, 29524, 3985
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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