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Invitrogen™ Phospho-LRP6 (Ser1490) Polyclonal Antibody
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Catalog No. PIPA5106064
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100 μL
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PIPA5106064 100 μL
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Catalog No. PIPA5106064 Supplier Invitrogen™ Supplier No. PA5106064
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of LRP6 only when phosphorylated at Ser1490.

LRP6 is essential for the Wnt/beta catenin signaling pathway, probably by acting as a coreceptor together with Frizzled for Wnt. It is a specific, high-affinity receptor for DKK1 and DKK2, but not DKK3. The interaction with DKK1 blocks LRP6-mediated Wnt/beta catenin signaling via LRP6 removal via Kremen proteins-mediated endocytosis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-LRP6 (Ser1490)
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene LRP6
Gene Accession No. O75581, O88572
Gene Alias ADCAD2; C030016K15Rik; Cd; crooked; FLJ90062; FLJ90421; Gw; LDL receptor related protein 6; low density lipoprotein receptor-related protein 6; low density lipoprotein receptor-related protein 6; low density lipoprotein-related protein 6; low density lipoprotein-related protein 6; low-density lipoprotein receptor-related protein 6; lpr6; LRP6; LRP-6; ska>m26Jus>; ska26; skax26; STHAG7
Gene Symbols LRP6
Host Species Rabbit
Immunogen A synthesized peptide derived from human LRP6(Accession O75581), corresponding to amino acid residues around phosphorylated Ser1490.
Purification Method Sequential Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 16974, 4040
Target Species Human, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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