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Phospho-MARCKS (Ser163) Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Supplier: Thermo Scientific PA538139
Description
Myristoylated alanine-rich protein kinase C substrate (MARCKS), also designated 80K or 80K-L, has been identified as a major cellular substrate for protein kinase C. Human MARCKS is a 332 amino acid protein with a calculated molecular weight of 31.534 kDa; however, it has been shown to run at 80-87 kDa on Western blot. The plasma membrane bound protein dissociates from the membrane upon phosphorylation by various PKC isoforms. In NIH/3T3 fibroblasts, PKC alpha and PKC epsilon, but not PKC delta, are responsible for MARCKS phosphorylation. MARCKS has been found to bind calmodulin, Actin and Synapsin and is a filamentous (F) Actin crosslinking protein.
Specifications
Phospho-MARCKS (Ser163) | |
Polyclonal | |
Unconjugated | |
MARCKS | |
80K-L protein, MACS, MARCS, Myristoylated alanine-rich C-kinase substrate, PKCSL, PRKCSL, Protein kinase C substrate, 81 kDa protein, light chain | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
17118, 25603, 4082 | |
-20°C | |
Liquid |
Immunohistochemistry (Paraffin) | |
1 mg/mL | |
Dulbecco′s PBS with 150mM NaCl, 50% glycerol and 0.02% sodium azide; pH 7.4 | |
P29966, P26645, P30009 | |
MARCKS | |
A synthetic phosphopeptide derived from human MARCKS around the phosphorylation site of Ser162 (K-K-SP-F-K) | |
100 μg | |
Primary | |
Human, Mouse, Rat | |
Antibody | |
IgG |
Safety and Handling
WARNING: Cancer - www.P65Warnings.ca.gov
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