Invitrogen™ Phospho-MEF2C (Ser222) Polyclonal Antibody

Catalog No.	Quantity
PIPA595673	100 μL

Catalog No. PIPA595673 Supplier Invitrogen™ Supplier No. PA595673

Description

Rabbit Polyclonal Antibody

Antigen Affinity Purified from Pooled Serum.

MEF2C is a transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B cells. May also be involved in neurogenesis and in the development of cortical architecture. Isoform 3 and isoform 4, which lack the repressor domain, are more active than isoform 1 and isoform 2.

Specifications

• Antigen: Phospho-MEF2C (Ser222)
• Applications: Western Blot
• Classification: Polyclonal
• Concentration: ~0.25 mg/mL
• Conjugate: Unconjugated
• Formulation: 10mM HEPES with 50% glycerol, 0.15M NaCl, 100μg/mL BSA and no preservative; pH 7.5
• Gene: MEF2C
• Gene Accession No.: Q06413
• Gene Alias: 5430401D19Rik; 9930028G15Rik; AV011172; C5DELq14.3; DEL5q14.3; hoo; hoover; id:ibd5026; MADS box transcription enhancer factor 2, polypeptide C; Mef2; mef2c; mef2c protein; mef2ca; Myocyte enhancer factor 2C; myocyte enhancer factor 2C MEF2C; myocyte enhancer factor 2ca; myocyte enhancer factor 2ca 4'-6'; myocyte enhancer factor 2ca delta gamma-like; myocyte enhancer factor 2ca variant 4; myocyte enhancer factor 2ca variant 5; myocyte enhancer factor 2ca variant 6; myocyte enhancer factor 2ca; myocyte-specific enhancer factor 2C; myocyte-specific enhancer factor 2C; RGD1563119; wu:fc05b06; zgc:64184; zgc:85726
• Gene Symbols: MEF2C
• Host Species: Rabbit
• Immunogen: Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser222 conjugated to KLH.
• Purification Method: Antigen Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 4208
• Target Species: Human
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG