Invitrogen™ Phospho-MEK1 (Ser298) Recombinant Rabbit Monoclonal Antibody (MEK1S298-H8)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA537069

Catalog No. PIMA537069

Description

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

MAP2K1 (MEK1) kinase is a dual-specificity protein kinase that functions in mitogen-activated protein kinase (MAPK) cascades, controlling cell growth and differentiation. MAP2K1 is activated by a wide variety of growth factors and cytokines and also by membrane-dependent depolarization and calcium influx. Mek1 is activated by phosphorylation of serine 218 and 222 residues by Raf1. It is known to be involved in the signaling during stress activate response, apoptosis and proliferative induction by cytokines. Mutations in the gene can lead to cardiofaciocutaneous syndrome.

Specifications

• Antigen: Phospho-MEK1 (Ser298)
• Classification: Recombinant Monoclonal
• Concentration: 0.5 mg/mL
• Formulation: PBS with 0.1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q01986, Q02750
• Gene Symbols: Map2k1
• Immunogen: A synthetic phospho-peptide corresponding to residues surrounding Ser298 of human phospho MEK1.
• Quantity: 20 μL
• Primary or Secondary: Primary
• Target Species: Human, Rat
• Product Type: Antibody
• Isotype: IgG κ

• Applications: Flow Cytometry, Western Blot
• Clone: MEK1S298-H8
• Conjugate: Unconjugated
• Gene: Map2k1
• Gene Alias: CFC3; dual specificity mitogen activated protein kinase kinase 1; dual specificity mitogen-activated protein kinase kinase 1; EC 2.7.12.2; ERK activator kinase 1; kinase MEK1; MAP kinase kinase 1; MAP kinase kinase or Erk Kinase, Dual specificity mitogen-activated protein kinase kinase, involved in ras mediated vulval induction, LEThal LET-537 (42.8 kD) (mek-2); MAP kinase/Erk kinase 1; Map2k1; map2k1.L; MAPK/ERK kinase 1; MAPKK 1; MAPKK1; MEK 1; Mek1; MEK2; mek-2; MEKK1; mitogen activated protein kinase kinase 1; mitogen-activated protein kinase kinase 1; mitogen-activated protein kinase kinase 1 L homeolog; MKK (Thr292); MKK (Thr386); MKK1; MKK2; MP2K1; Prkmk1; PRKMK2; protein kinase, mitogen activated, kinase 1, p45; protein kinase, mitogen-activated, kinase 1 (MAP kinase kinase 1); XELAEV_18018447mg
• Host Species: Rabbit
• Purification Method: Protein A/G
• Regulatory Status: RUO
• Gene ID (Entrez): 170851, 5604
• Content And Storage: -20°C
• Form: Liquid