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Invitrogen™ Phospho-MEKK1 (Thr1400) Polyclonal Antibody
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Catalog No. PIPA5103271
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PIPA5103271 100 μL
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Catalog No. PIPA5103271 Supplier Invitrogen™ Supplier No. PA5103271
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of MEKK1 only when phosphorylated at Thr1400, which site historically referenced as Thr1402.

Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MEKK1 can phosphorylate and activate MAPKK 1 and MAPKK 2 (MEK1/MEK2) which leads to phosphorylation of MAP kinases. It is also a highly efficient activator of the JNK cascade. The protein contains a putative 1 RING-type zinc finger and 1 SWIM-type zinc finger.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-MEKK1 (Thr1400)
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene MAP3K1
Gene Accession No. P53349, Q13233, Q62925
Gene Alias MAP/ERK kinase kinase 1; MAP3K1; MAPK/ERK kinase kinase 1; MAPKKK1; MEK kinase 1; MEKK; MEKK 1; Mekk1; mitogen activated protein kinase kinase kinase 1; mitogen-activated protein kinase kinase kinase 1; mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase; si:rp71-80a19.2; SRXY6
Gene Symbols MAP3K1
Host Species Rabbit
Immunogen A synthesized peptide derived from human MAP3K1(Accession Q13233), corresponding to amino acid residues around phosphorylated Thr1400.
Purification Method Sequential Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 116667, 26401, 4214
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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