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Invitrogen™ Phospho-MKP3 (Ser197) Polyclonal Antibody
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Catalog No. PIPA5106011
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PIPA5106011 100 μL
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Catalog No. PIPA5106011 Supplier Invitrogen™ Supplier No. PA5106011
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of DUSP6 only when phosphorylated at Ser197.

DUSP6 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP)kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associatedwith cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Twotranscript variants encoding different isoforms have been found for the DUSP6 gene.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-MKP3 (Ser197)
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene DUSP6
Gene Accession No. Q16828, Q64346, Q9DBB1
Gene Alias 1300019I03Rik; dual specificity phosphatase 6; dual specificity protein phosphatase 6; Dual specificity protein phosphatase PYST1; Dusp6; DUSP6-ALT; HH19; MAP kinase phosphatase 3; mitogen-activated protein kinase phosphatase 3; Mkp3; MKP-3; PYST1; serine/threonine specific protein phosphatase
Gene Symbols DUSP6
Host Species Rabbit
Immunogen A synthesized peptide derived from human DUSP6(Accession Q16828), corresponding to amino acid residues around phosphorylated Ser197.
Purification Method Sequential Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 116663, 1848, 67603
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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