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Invitrogen™ Phospho-MNK1 (Thr250) Polyclonal Antibody
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Catalog No. PIPA5105901
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PIPA5105901 100 μL
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Catalog No. PIPA5105901 Supplier Invitrogen™ Supplier No. PA5105901
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of Mnk1 only when phosphorylated at Thr250.

The Map kinase-interacting kinases (MKNK1 and MKNK2) are activated by Map kinases, regulate protein synthesis by phosphroylation eIF4E on Ser209, and may contribute to tumorigenesis. Overexpression of Mnk2 results in increased phosphorylation of endogenous eIF-4E, showing that it can act as an eIF-4E kinase in vivo. Mnk2 may play a role in the response to environmental stress and cytokines. Expression of active mutants of MNK1 and MNK2 in 293 cells diminishes cap-dependent translation relative to cap-independent translation in a transient reporter assay. Human Mnk2 is homologous to murine Mnk2 (approximately 94% identical) and human Mnk1 (71% identical). In vitro phosphorylation studies show that Mnk2 is a significantly better substrate than Mnk1 for extracellular signal-regulated kinase 2 (Erk2), p38MAPKalpha, and p38MAPKbeta.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-MNK1 (Thr250)
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene MKNK1
Gene Accession No. O08605, Q4G050, Q9BUB5
Gene Alias 2410048M24Rik; MAP kinase interacting serine/threonine kinase 1; MAP kinase signal-integrating kinase 1; MAP kinase-interacting serine/threonine kinase 1; MAP kinase-interacting serine/threonine-protein kinase 1; MAPK signal-integrating kinase 1; MKNK1; Mnk1; OTTHUMP00000009675; OTTHUMP00000009676
Gene Symbols MKNK1
Host Species Rabbit
Immunogen A synthesized peptide derived from human MKNK1(Accession Q9BUB5), corresponding to amino acid residues around phosphorylated Thr250.
Purification Method Sequential Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 17346, 500526, 8569
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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