Phospho-MRE11 (Ser264) Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA538868

Catalog No. PIPA538868

Description

MRE11 (double-strand break repair protein MRE11) is a component of the MRN complex. This complex plays a central role in double-strand break repair, DNA recombination, maintece of telomere integrity and meiosis. The complex possesses single-stranded endonuclease activity and double-strand-specific 3′-5′ exonuclease activity which are provided by MRE11. RAD50 is required to bind DNA ends and hold them in close proximity. Mutations in the gene could result in ataxia-telangiectasia-like disorder 1.

Specifications

• Antigen: Phospho-MRE11 (Ser264)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: MRE11
• Gene Alias: AT-like disease, DNA recombination and repair protein, MRE11 homolog 1, MRE11 homolog A, double-strand break repair protein MRE11A, endo/exonuclease Mre11, meiotic recombination 11 homolog 1, meiotic recombination 11 homolog A
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 17535, 4361
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: Dulbecco′s PBS with 150mM NaCl, 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: P49959, Q61216
• Gene Symbols: MRE11, Mre11a
• Immunogen: A synthetic phosphopeptide derived from human MRE11 around the phosphorylation site of Ser264 (Y-I-SP-Q-P)
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG