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Phospho-MSK1 (Thr581) Recombinant Rabbit Monoclonal Antibody (MSK1T581-A5), APC, Invitrogen™

Rabbit Recombinant Monoclonal Antibody

$245.00 - $598.50

Specifications

Antigen Phospho-MSK1 (Thr581)
Clone MSK1T581-A5
Applications Flow Cytometry
Classification Recombinant Monoclonal
Conjugate APC
View More Specs

Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
PIMA537291
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Invitrogen™
MA537291
10 Tests
Each for $245.00
Only null left
Add to Cart
 
PIMA537015
View Documents
Invitrogen™
MA537015
100 Tests
Each for $598.50
Only null left
Add to Cart
 
Description

Description

RPS6KA5 (MSK1) is a serine/threonine protein kinase that is essential for the regulation of various cellular processes. RPS6KA5 is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF and upon glucocorticoid, associates in the cytoplasm with the glucocorticoid receptor NR3C1 and contributes to RELA inhibition and repression of inflammatory gene expression. In skeletal myoblasts is required for phosphorylation of RELA at 'Ser-276' during oxidative stress. In erythropoietin-stimulated cells, is necessary for the 'Ser-727' phosphorylation of STAT3 and regulation of its transcriptional potential.
Specifications

Specifications

Phospho-MSK1 (Thr581)
Flow Cytometry
APC
Rabbit
Human, Mouse, Rat
O75582, Q8C050
314384, 73086, 9252
A synthetic phospho-peptide corresponding to residues surrounding Thr581 of human phospho MSK1.
Primary
4°C
Rps6ka5
MSK1T581-A5
Recombinant Monoclonal
Liquid
RUO
PBS with 0.20% BSA and 0.09% sodium azide
3110005L17Rik; 6330404E13Rik; 90 kDa ribosomal protein S6 kinase 5; AI854034; kinase MSK1; KS6A5; mitogen and stress-activated protein kinase 1; Msk1; MSPK1; Nuclear mitogen- and stress-activated protein kinase 1; ribosomal protein S6 kinase A5; ribosomal protein S6 kinase alpha-5; ribosomal protein S6 kinase, 90kDa, polypeptide 5; ribosomal protein S6 kinase, polypeptide 5; RLPK; RLSK; Rps6ka5; RSKL; RSK-like protein kinase; S6K-alpha-5
Rps6ka5
IgG κ
Protein A/G
Antibody
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Documents

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