Invitrogen™ Phospho-NACA (Ser43) Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5118704

Catalog No. PIPA5118704

Description

Antibody detects endogenous levels of NACA only when phosphorylated at Ser43.

NACA prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). It binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. NACA also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites), and may act as a specific coactivator for JUN, binding to DNA and stabilizing the interaction of JUN homodimers with target gene promoters.

Specifications

• Antigen: Phospho-NACA (Ser43)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: NACA
• Gene Alias: AL022831; AL024382; Alpha-NAC; Alpha-NAC, muscle-specific form; alpha-NAC/1.9.2; Gm1878; Hom s 2; HSD48; mKIAA0363; NACA; NACA1; NAC-alpha; nascent polypeptide-associated complex alpha polypeptide; nascent polypeptide-associated complex alpha subunit; nascent polypeptide-associated complex subunit alpha; Nascent polypeptide-associated complex subunit alpha, muscle-specific form; nascent-polypeptide-associated complex alpha polypeptide; skNAC
• Host Species: Rabbit
• Purification Method: Sequential Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 17938, 288770, 4666
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: E9PAV3, P70670, Q13765, Q60817
• Gene Symbols: NACA
• Immunogen: A synthesized peptide derived from human NACA(Accession Q13765), corresponding to amino acid residues around phosphorylated Ser43.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG