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Invitrogen™ Phospho-NDRG1 (Thr346) Recombinant Rabbit Monoclonal Antibody (NDRG1T346-F5)

Catalog No. PIMA527982
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200 μL
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PIMA527982 200 μL
PIMA536981 20 μL
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Catalog No. PIMA527982 Supplier Invitrogen™ Supplier No. MA527982
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Rabbit Recombinant Monoclonal Antibody

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

NDRG1 is a 394 amino acid cytoplasmic protein belonging to the NDRG family. It interacts with APO A-I and A-II and plays a role in HDL-mediated cholesterol transport, stress responses, hormone responses, cell growth and differentiation. Its defect causes Charcot-Marie-Tooth disease type 4D (CMT4D) that is characterized by reduced nerve conduction velocities, segmental demyelination and remyelination with onion bulb formations on nerve biopsy, slowly progressive distal muscle atrophy and weakness, absent deep tendon reflexes and hollow feet. NDRG1 plays a growth inhibitory role and serves as a marker of differentiation. It is expressed in placental membranes, prostate, kidney, small intestine, ovary tissues, colon and the cells that border the lumen.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-NDRG1 (Thr346)
Applications Flow Cytometry, Western Blot
Classification Recombinant Monoclonal
Clone NDRG1T346-F5
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol, 0.1% BSA and 0.02% sodium azide; pH 7.4
Gene NDRG1
Gene Accession No. Q62433, Q92597
Gene Alias CAP43; CMT4D; differentiation-related gene 1 protein; DRG1; DRG-1; GC4; HMSNL; Ndr1; Ndrg1; Ndrl; nickel-specific induction protein Cap43; NMSL; N-myc downstream regulated 1; N-myc downstream regulated gene 1; N-myc downstream-regulated gene 1 protein; Protein Ndr1; protein NDRG1; protein regulated by oxygen-1; PROXY1; Reducing agents and tunicamycin-responsive protein; Rit42; RTP; TARG1; TDD5
Gene Symbols NDRG1
Host Species Rabbit
Immunogen A synthetic phospho-peptide corresponding to residues surrounding Thr346 of human phospho NDRG1.
Purification Method Protein A/G
Quantity 200 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 10397, 17988
Target Species Human, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG κ
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