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Phospho-NEDD4L (Ser342) Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501985288
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50-198-5288 100 μL
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Catalog No. 50-198-5288 Supplier Bioss Supplier No. BS3299R
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Description

Rabbit Polyclonal Antibody

NEDD4L is an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. NEDD4L inhibits TGF-beta signaling by triggering SMAD2 and TGFR1 ubiquitination and proteasome-dependent degradation. NEDD4L promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, EAAT1 or CLC5. NEDD4L also promotes ubiquitination and degradation of SGK.

Specifications

Antigen Phospho-NEDD4L (Ser342)
Applications Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene NEDD4L
Gene Accession No. Q96PU5
Gene Alias 1300012C07Rik; BOS_22342; E3 ubiquitin-protein ligase NEDD4-like; FLJ33870; HECT-type E3 ubiquitin transferase NED4L; hNEDD4-2; KIAA0439; NEDD4; NEDD4.2; Nedd4-2; Nedd4b; NEDD4L; NEDL3; neural precursor cell expressed, developmentally down-regulated 4-like; neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase; neural precursor cell expressed, developmentally down-regulated gene 4b; neural precursor cell expressed, developmentally down-regulated gene 4-like; RSP5; ubiquitin-protein ligase Nedd4-2; ubiquitin-protein ligase Rsp5
Gene Symbols NEDD4L
Host Species Rabbit
Immunogen KLH conjugated synthetic phosphopeptide derived from human NEDD4L around the phosphorylation site of Ser342.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 23327
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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