Invitrogen™ Phospho-NEK9 (Thr210) Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA575152

Catalog No. PIPA575152

Description

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 100% (by SDS-PAGE).

NEK9, a NEK type protein kinase, regulates chromosome alignment and segregation in mitosis. The protein has a N-terminal NIMA-like catalytic domain, a central domain with homology to the guanine nucleotide exchange factor for the GTPase Ran (RCC1), and a C-terminal coiled-coil domain. It is phosphorylated by active p34(Cdc2) and is capable of autophosphorylation and oligomerization. The activated protein binds Nek6 and RCC1, and has been shown to associate with the human homolog of the Drosophila protein Bicaudal D (Bicd2) in vivo and to phosphorylate this coiled-coil protein in vitro. NEK9 expression has been documented in normal human brain. ESTs have been isolated from several tissue libraries, including normal bone, lymph and thymus and cancerous cervix, eye, lymph and placenta.

Specifications

• Antigen: Phospho-NEK9 (Thr210)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: NEK9
• Gene Alias: APUG; C130021H08Rik; DKFZp434D0935; KIAA1995; LCCS10; MGC138306; MGC16714; NC; NEK 9; NEK8; NEK9; Nercc; Nercc 1 kinase; NERCC1; Nercc1 kinase; never in mitosis A-related kinase 9; NIMA (never in mitosis gene a)- related kinase 9; NIMA (never in mitosis gene a)-related expressed kinase 9; NIMA related kinase 9; NimA-related kinase 8; NIMA-related kinase 9; nimA-related protein kinase 9; Serine/threonine-protein kinase Nek9
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 217718, 91754
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 15mM sodium azide; pH 7.2
• Gene Accession No.: Q8K1R7, Q8TD19
• Gene Symbols: NEK9
• Immunogen: Synthetic phosphopeptide derived from human NEK9 around the phosphorylation site of Threonine 210.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov