Invitrogen™ Phospho-Nephrin (Tyr1176) Polyclonal Antibody

Catalog No.	Quantity
PIPA5105709	100 μL

Catalog No. PIPA5105709 Supplier Invitrogen™ Supplier No. PA5105709

Description

Rabbit Polyclonal Antibody

Phospho-Nephrin (Tyr1176) Antibody detects endogenous levels of Nephrin only when phosphorylated at Tyr1176.

Primary steroid resistant nephrotic syndrome (SRNS) is characterized by childhood onset of proteinuria and progression to end stage renal disease. Kidney podocytes and their slit diaphragms form the final barrier to urinary protein loss. Congenital nephrotic syndrome (CNS) is caused by mutations in NPHS1 (nephrin) or NPHS2. Nephrin, a recently identified protein is a member of a group of podocyte proteins that constitute major component of the slit diaphragm especially in the foot process. Nephrin, a cell adhesion molecule, may play a crucial role in maintaining the glomerular filtration barrier. Recent studies have suggested that mutations in the gene for Nephrin reportedly lead to congenital nephrosis. Three novel podocyte proteins, Podocin, Nephrin and alpha Actinin 4 have been identified in congenital and experimental models of proteinuria. The role of Nephrin in anti apoptotic activity in podocyte slit diaphragm is believed to be associated with vascular endothelial derived growth factors VEGF signaling. Nephrin seems to play a role in the development or function of the kidney glomerular filtration barrier and it may anchor the podocyte slit diaphragm to the actin cytoskeleton.

Specifications

• Antigen: Phospho-Nephrin (Tyr1176)
• Applications: Western Blot
• Classification: Polyclonal
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene: Nphs1
• Gene Accession No.: O60500, Q9QZS7
• Gene Alias: CNF; Nephrin; nephrin 1; NephrinB; nephrosis 1 homolog, nephrin; nephrosis 1, congenital, Finnish type (nephrin); nephrosis 1, nephrin; NPHN; NPHS1; NPHS1 nephrin; NPHS1, nephrin; renal glomerulus-specific cell adhesion receptor
• Gene Symbols: Nphs1
• Host Species: Rabbit
• Immunogen: A synthesized peptide derived from human NPHS1(Accession O60500), corresponding to amino acid residues around phosphorylated Tyr1176.
• Purification Method: sequential chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 4868, 54631
• Target Species: Human, Mouse
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG

Safety and Handling

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