Phospho-NFATC1 (Ser294) Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA538301

Catalog No. PIPA538301

Description

The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Five transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes.

Specifications

• Antigen: Phospho-NFATC1 (Ser294)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: NFATC1
• Gene Alias: NF-ATC, NFAT2, NFATc, NF-ATc1, NFAT transcription complex cytosolic component, nuclear factor of activated T-cells, cytoplasmic 1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 18018, 4772
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 1 mg/mL
• Formulation: Dulbecco′s PBS with 150mM NaCl, 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: O95644, O88942
• Gene Symbols: NFATC1
• Immunogen: A synthetic phosphopeptide derived from human NFAT2 around the phosphorylation site of Ser294 (R-V-SP-V-T)
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG