Invitrogen™ NMDAR1 Monoclonal Antibody (N308/48), APC

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA545562

Catalog No. PIMA545562

Description

1 μg/mL of MA5-45562 was sufficient for detection of NR1 glutamate receptor in 20 μg of rat brain membrane lysate and assayed by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody. Detects approximately 105kDa. This antibody was formerly sold as clone S308-48.

NMDAR1 encodes a protein that is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described.

Specifications

• Antigen: NMDAR1
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: 2.48 mM MES, 95.64 mM phosphate with 0.5M EDTA and no preservative; pH 7.4
• Gene Accession No.: P35438, P35439, Q05586
• Gene Symbols: GRIN1
• Immunogen: Fusion protein amino acids 42-361 (extracellular N-terminus) of rat NR1.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG1

• Applications: Immunohistochemistry, Western Blot, Immunocytochemistry
• Clone: N308/48
• Conjugate: APC
• Gene: GRIN1
• Gene Alias: GluN1; Glun1r; GluRdelta1; Glurz1; GluRzeta1; glutamate [NMDA] receptor subunit zeta 1; glutamate [NMDA] receptor subunit zeta-1; glutamate ionotropic receptor NMDA type subunit 1; glutamate receptor; glutamate receptor ionotropic, NMDA 1; glutamate receptor subunit zeta 1; glutamate receptor, ionotropic, NMDA1 (zeta 1); glutamate receptor, ionotropic, N-methyl D-aspartate 1; GRIN1; M100174; MRD8; neurotransmitter receptor; NMDA R1 receptor C1 cassette; NMDA receptor 1; NMDA1; Nmdar; NMDAR1; NMD-R1; NMDZ1; N-methyl-D-aspartate glutamate receptor; N-methyl-D-aspartate receptor 1; N-methyl-D-aspartate receptor channel, subunit zeta-1; N-methyl-D-aspartate receptor subunit NR1; NMZ1; NR1; NR1C1; NR1C2; NR1C2'; NR1N1; pGluN1; Rgsc174; RP11-350O14.1
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 14810, 24408, 2902
• Content And Storage: 4°C
• Form: Liquid

Safety and Handling

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