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Invitrogen™ Phospho-NOTCH3 (Ser84) Polyclonal Antibody
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Catalog No. PIPA5105323
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100 μL
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PIPA5105323 100 μL
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Catalog No. PIPA5105323 Supplier Invitrogen™ Supplier No. PA5105323
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of NOTCH3 only when phosphorylated at Ser84.

NOTCH3 is the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction (with its cell-bound ligands delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human. NOTCH3 functions as a receptor for membrane-bound ligands Jagged1, Jagged2, and Delta1 to regulate cell-fate determination. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).
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Specifications

Antigen Phospho-NOTCH3 (Ser84)
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Notch3
Gene Accession No. Q61982, Q9R172, Q9UM47
Gene Alias AW229011; CADASIL; CADASIL1; CASIL; hpbk; IMF2; LMNS; N3; Neurogenic locus notch homolog protein 3; notch 3; Notch 3 extracellular truncation; Notch 3 intracellular domain; Notch gene homolog 3; Notch homolog 3; NOTCH3
Gene Symbols Notch3
Host Species Rabbit
Immunogen A synthesized peptide derived from human NOTCH3(Accession Q9UM47), corresponding to amino acid residues around phosphorylated Ser84.
Purification Method sequential chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 18131, 4854, 56761
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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