Phospho-Nuclear receptor ROR gamma (Ser203) Polyclonal Antibody, Rockland™

Rabbit Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-199-2081	Rockland Immunochemicals 600401GR8	100 μg
50-199-2082	Rockland Immunochemicals 600401GR8S	25 μL

Description

Store vial at -20°C prior to opening. Aliquot contents and freeze at -20°C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. Anti-nuclear receptor ROR gamma pS203 is directed against mouse receptor ROR gamma phosphorylated at the serine 203 position. A BLAST analysis was used to suggest reactivity with this protein with pongo abelii based on 100% homology for the immunogen sequence.

ROR gamma, a NR1 Thyroid Hormone-Like receptor, has been shown to affect thymopoiesis, bone metabolism, T-cell apoptosis, and lymphoid organogenesis. ROR gamma has been shown to promote thymocyte survival by activating the expression of the antiapoptotic protein Bcl-x(L). ROR gamma is also required for the development of lymph nodes and Peyer's patches. It has been shown that ROR gamma(t), a thymus-specific isoform of ROR gamma from mouse, inhibits Fas ligand expression and cytokine secretion in immature thymocytes. ROR gamma binds as a monomer to response elements composed of a single core motif, GGTCA, preceded by a 6 bp AT-rich sequence. ROR gamma expression has been documented in mouse thymus, adipose, bone, skeletal muscle, liver, and kidney, and in human skeletal muscle. ESTs have been isolated from human tissue libraries, including cancerous head/neck, germ cell, and prostate, and normal colon, head/neck, lung, liver/spleen, and pancreas.

Specifications

• Antigen: Phospho-Nuclear receptor ROR gamma (Ser203)
• Applications: ELISA, Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Mouse
• Gene Accession No.: P51450
• Gene ID (Entrez): 19885
• Primary or Secondary: Primary
• Product Type: Antibody

• Concentration: 1.05 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: 0.02M potassium phosphate with 0.15M NaCl and 0.01% sodium azide; pH 7.2
• Gene Alias: EGK_01272; IMD42; MGC129539; Nr1f3; Nuclear receptor ROR-gamma; Nuclear receptor RZR-gamma; Nuclear receptor subfamily 1 group F member 3; RAR related orphan receptor C; RAR-related orphan nuclear receptor variant 2; RAR-related orphan receptor C; RAR-related orphan receptor C, isoform a; RAR-related orphan receptor gamma; retinoic acid-binding receptor gamma; retinoid-related orphan receptor gamma; Retinoid-related orphan receptor-gamma; ROR Gamma; Rorc; RORG; RORgamma; RP11-98D18.11-001; RZRG; RZR-GAMMA; Thor; Thymus orphan receptor; TOR
• Gene Symbols: Rorc
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Gene: Rorc