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Invitrogen™ Phospho-NUMB (Ser276) Polyclonal Antibody
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Catalog No. PIPA5105176
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PIPA5105176 100 μL
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Catalog No. PIPA5105176 Supplier Invitrogen™ Supplier No. PA5105176
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of NUMB only when phosphorylated at Ser276.

Protein NUMB homolog is an evolutionarily conserved protein that controls the differentiation of neuronal progenitor cells. Recent studies have revealed that NUMB functions in clathrin-dependent endocytosis by binding to the AP-2 complex. NUMB is also expressed in postmitotic neurons and plays a role in axonal growth. Neural cells expressing Numb isoforms with short phosphotyrosine-binding (SPTB) domain undergo extensive neurite outgrowth, an effect that can be blocked by voltage-gated Ca2+ channel (VGCC) inhibitor or by Ca2+ chelator.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-NUMB (Ser276)
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Numb
Gene Accession No. P49757, Q2LC84, Q9QZS3
Gene Alias c14_5527; C14orf41; h-Numb; mnb; m-Nb; m-numb; Nb; NUMB; NUMB endocytic adaptor protein; numb gene homolog; numb gene homolog (Drosophila); numb homolog; numb homolog (Drosophila); NUMB isoform 3; Numb variant 1; Numb variant 2; NUMB, endocytic adaptor protein; protein numb homolog; Protein S171; PTB domain protein; S171
Gene Symbols Numb
Host Species Rabbit
Immunogen A synthesized peptide derived from human NUMB(Accession P49757), corresponding to amino acid residues around phosphorylated Ser276.
Purification Method sequential chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 18222, 29419, 8650
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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