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Invitrogen™ Phospho-Occludin (Ser507 ) Polyclonal Antibody
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Catalog No. PIPA5105057
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100 μL
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PIPA5105057 100 μL
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Catalog No. PIPA5105057 Supplier Invitrogen™ Supplier No. PA5105057
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of Occludin only when phosphorylated at Ser507(mouse).

Occludin is a 65 kDa protein that can exist in a variety of phosphorylated forms, ranging up to approximately 82 kDa. Occludin is thought to be involved in regulating both the localization and the function of occludin. Polyunsaturated fatty acids are known to up-regulate occludin expression, increasing the transendothelial cell resistance and reducing the cellular permeability to large molecules. The level of occludin varies greatly depending on tissue; in brain tissue, occludin is highly and continuously expressed at cell-cell contact sites, whereas non-neural tissues show lower expression and discontinuous distribution. Overall structural features of the occludin protein are highly conserved in all the species examined. Under-expression of tight junction proteins, including occludin, is a key molecular abnormality responsible for the increased permeability of tumor endothelial tight junctions, which contributes to brain tumor edemas.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-Occludin (Ser507 )
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene OCLN
Gene Accession No. Q16625, Q61146, Q6P6T5
Gene Alias AI503564; BLCPMG; Occludin; occludin 1B; Ocl; Ocln; phosphatase 1, regulatory subunit 115; PPP1R115; tight junction protein occludin; tight junction structural protein
Gene Symbols OCLN
Host Species Rabbit
Immunogen A synthesized peptide derived from mouse OCLN(Accession Q16625), corresponding to amino acid residues around phosphorylated Ser507.
Purification Method Sequential Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 100506658, 18260, 83497
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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