Invitrogen™ Phospho-Oxytocin Receptor (Thr235) Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5105111

Catalog No. PIPA5105111

Description

Antibody detects endogenous levels of Oxytocin Receptor only when phosphorylated at Thr235.

The oxytocin receptor (OXTR) belongs to the G-protein coupled receptor family. Its activity is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. The receptor is made up of 389 amino acids and has a molecular weight of ~43,000 kDa. The oxytocin-oxytocin receptor system plays an important role as an inducer of uterine contractions during parturition and of milk ejection. Oxytocin receptors are expressed by the myoepithelial cells of the mammary gland, and in both the myometrium and endometrium or the uterus at the end of pregnancy. Additionally, oxytocin receptors are present in the central nervous system, mediating a variety of behaviors, including maternal behavior, bonding, social memory and recognition, sexual and aggressive behaviors, and stress and anxiety.

Specifications

• Antigen: Phospho-Oxytocin Receptor (Thr235)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Oxtr
• Gene Alias: Otr; OT-R; OTR1; oxcytocin receptor; OXTR; Oxt-r; Oxytocin receptor
• Host Species: Rabbit
• Purification Method: Sequential Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 18430, 25342, 5021
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: P30559, P70536, P97926
• Gene Symbols: Oxtr
• Immunogen: A synthesized peptide derived from human OXTR(Accession P30559), corresponding to amino acid residues around phosphorylated Thr235.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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