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Invitrogen™ Phospho-p130 (Ser639) Polyclonal Antibody
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Catalog No. PIPA5118748
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100 μL
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PIPA5118748 100 μL
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Catalog No. PIPA5118748 Supplier Invitrogen™ Supplier No. PA5118748
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of RBL2 only when phosphorylated at Ser639.

RBL2 (also known as p130) or Retinoblastoma-like protein 2 is a key regulator of entry into cell division. It is directly involved in heterochromatin formation by maintaining overall chromatin structure and (in particular) that of constitutive heterochromatin by stabilizing histone methylation. RBL2 recruits and targets histone methyltransferases KMT5B and KMT5C leading to epigenetic transcriptional repression. It controls histone H4 'Lys20' trimethylation. It probably also acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. RBL2 serves as a potent inhibitor of E2F-mediated trans-activation and associates preferentially with E2F5.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-p130 (Ser639)
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene RBL2
Gene Accession No. O55081, Q08999, Q64700
Gene Alias 130 kDa retinoblastoma-associated protein; FLJ26459; p130; PPAR-alpha-interacting complex protein 128; PRB2; PRIC128; RB transcriptional corepressor like 2; Rb2; rb2 p130; Rbl2; RBR-2; retinoblastoma-like 2; retinoblastoma-like 2 (p130); retinoblastoma-like protein 2; Retinoblastoma-related protein 2
Gene Symbols RBL2
Host Species Rabbit
Immunogen A synthesized peptide derived from human RBL2(Accession Q08999), corresponding to amino acid residues around phosphorylated Ser639.
Purification Method Sequential Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 19651, 5934, 81758
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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