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Phospho-p38 MAPK (Thr179, Tyr181) Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Supplier: Thermo Scientific PA538416
Description
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases, or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Specifications
Phospho-p38 MAPK (Thr179, Tyr181) | |
Polyclonal | |
Unconjugated | |
MAPK14 | |
CRK1, CSAID binding protein, CSBP, CSBP1, CSBP2, Cytokine suppressive anti- inflammatory drug binding protein, EC 2.7.11.24, MAP kinase MXI2, MAP kinase p38, MAPK14, MAX-interacting protein 2, MK14, MXI2, Mitogen-activated protein kinase 14 | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
5600, 81649, 689314, 1432, 19094, 26416 | |
-20°C | |
Liquid |
Western Blot | |
1 mg/mL | |
Dulbecco′s PBS with 150mM NaCl, 50% glycerol and 0.02% sodium azide; pH 7.4 | |
Q16539, P47811, P70618, Q15759, Q9WUI1 | |
MAPK11, MAPK14 | |
A synthetic phosphopeptide derived from human p38 MAPK around the phosphorylation site of Thr179 and Tyr181 (E-M-TP-G-YP-V-A) | |
100 μg | |
Primary | |
Human, Mouse, Rat | |
Antibody | |
IgG |
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