Invitrogen™ Phospho-p38 MAPK beta (Thr180, Tyr182) Recombinant Rabbit Monoclonal Antibody (RM243)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA533089

Catalog No. PIMA533089

Description

Specificity: reacts to p38 MAPK only when dual phosphorylation at Thr180 and Tyr182 is observed. There is no cross-reactivity with p38 MAPK without dual phosphorylation at Thr180 and Tyr182. Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

MAPK11 (p38 beta) is a serine/threonine kinase which is involved in a variety of cellular processes, and is activated by proinflammatory cytokines and environmental stress. Mitogen-activated protein kinase 11. The protein encoded by p38 MAPK beta is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. This kinase is most closely related to p38 MAP kinase, both of which can be activated by proinflammatory cytokines and environmental stress. This kinase is activated through its phosphorylation by MAP kinase kinases (MKKs), preferably by MKK6. Transcription factor ATF2/CREB2 has been shown to be a substrate of this kinase.

Specifications

• Antigen: Phospho-p38 MAPK beta (Thr180, Tyr182)
• Classification: Recombinant Monoclonal
• Concentration: 0.2 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide
• Gene Accession No.: Q15759
• Gene Symbols: MAPK11
• Immunogen: A phospho-peptide corresponding to human Phosphop38 MAPK (Thr180/Tyr182).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Clone: RM243
• Conjugate: Unconjugated
• Gene: MAPK11
• Gene Alias: MAP kinase 11; MAP kinase p38 beta; MAPK 11; Mapk11; mitogen activated protein kinase 11; mitogen-activated protein kinase 11; Mitogen-activated protein kinase p38 beta; mitogen-activated protein kinase p38-2; OTTHUMP00000196655; p38-2; P38b; p38beta; P38BETA2; Prkm11; protein kinase, mitogen activated kinase, 11, p38beta; SAPK2; SAPK2b; Stress-activated protein kinase 2b; stress-activated protein kinase-2; stress-activated protein kinase-2b
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 5600
• Content And Storage: -20°C
• Form: Liquid