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Phospho-p40phox (Thr154) Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501985448
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50-198-5448 100 μL
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Catalog No. 50-198-5448 Supplier Bioss Supplier No. BS3497R
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Description

Rabbit Polyclonal Antibody

The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Specifications

Antigen Phospho-p40phox (Thr154)
Applications Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene Ncf4
Gene Accession No. Q15080
Gene Alias AI451400; CGD3; CTA-833B7.1; MGC3810; NCF; NCF4; NCF-4; Neutrophil cytosol factor 4; neutrophil cytosolic factor 4; neutrophil cytosolic factor 4, 40kDa; Neutrophil NADPH oxidase factor 4; OTTHUMP00000028736; OTTHUMP00000043756; p40phox; p40-phox; SH3 and PX domain-containing protein 4; SH3PXD4
Gene Symbols Ncf4
Host Species Rabbit
Immunogen KLH conjugated synthetic phosphopeptide derived from human p40phox around the phosphorylation site of Thr154.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 4689
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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